Retrospective 770 COVID-19 patients with cancer, showing increased mortality with aspirin use in unadjusted results.
Pérez-Segura et al., 10/4/2021, retrospective, multiple countries, multiple regions, peer-reviewed, 23 authors.
risk of death, 49.1% higher, RR 1.49, p < 0.001, treatment 66 of 155 (42.6%), control 183 of 608 (30.1%), odds ratio converted to relative risk.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.