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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Hospitalization 67% Improvement Relative Risk Progression 19% Progression (b) 6% primary c19aspirin.com Connors et al. NCT04498273 Aspirin RCT EARLY TREATMENT Favors aspirin Favors control
Connors, 280 patient aspirin early treatment RCT: 67% lower hospitalization [p=0.49] and 19% lower progression [p=0.78] https://c19p.org/connors
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Effect of Antithrombotic Therapy on Clinical Outcomes in Outpatients With Clinically Stable Symptomatic COVID-19
Connors et al., JAMA, doi:10.1001/jama.2021.1727283
11 Oct 2021    Source   PDF   Share   Tweet
Early terminated RCT with 164 aspirin and 164 control patients in the USA with very few events, showing no significant difference with aspirin treatment for the combined endpoint of all-cause mortality, symptomatic venous or arterial thromboembolism, myocardial infarction, stroke, and hospitalization for cardiovascular or pulmonary indication. There was no mortality and no major bleeding events among participants that started treatment (there was one ITT placebo death). ACTIV-4B. NCT04498273.
risk of hospitalization, 67.3% lower, RR 0.33, p = 0.49, treatment 0 of 144 (0.0%), control 1 of 136 (0.7%), NNT 136, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), hospitalization for cardiovascular or pulmonary indication, suspected, started treatment.
risk of progression, 19.0% lower, RR 0.81, p = 0.78, treatment 6 of 144 (4.2%), control 7 of 136 (5.1%), NNT 102, acute medical event, suspected, started treatment.
risk of progression, 5.6% lower, RR 0.94, p = 1.00, treatment 1 of 144 (0.7%), control 1 of 136 (0.7%), NNT 2448, combined endpoint of all-cause mortality, symptomatic venous or arterial thromboembolism, myocardial infarction, stroke, and hospitalization for cardiovascular or pulmonary indication, suspected, started treatment, primary outcome.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Connors et al., 10/11/2021, Double Blind Randomized Controlled Trial, placebo-controlled, USA, North America, peer-reviewed, 27 authors, trial NCT04498273.
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