Aspirin for COVID-19: real-time analysis of all 7 studies

Home

Database of all aspirin COVID-19 studies. Submit updates/corrections.


Jul 30	Late	Abdelwahab et al., Clinical Drug Investigation, doi:10.1007/s40261-021-01061-2 (Peer Reviewed)	ventilation, ↑7.8%, p=0.93	Acetylsalicylic Acid Compared with Enoxaparin for the Prevention of Thrombosis and Mechanical Ventilation in COVID-19 Patients: A Retrospective Cohort Study
	Details Retrospective 225 hospitalized patients in Egypt, showing significantly lower thromboembolic events with aspirin treatment, but no significant difference in the need for mechanical ventilation.
Jul 30	Details Source PDF Late treatment study Late treatment study
	Abdelwahab et al., Clinical Drug Investigation, doi:10.1007/s40261-021-01061-2 (Peer Reviewed)
	Acetylsalicylic Acid Compared with Enoxaparin for the Prevention of Thrombosis and Mechanical Ventilation in COVID-19 Patients: A Retrospective Cohort Study
	Retrospective 225 hospitalized patients in Egypt, showing significantly lower thromboembolic events with aspirin treatment, but no significant difference in the need for mechanical ventilation. risk of mechanical ventilation, 7.8% higher, RR 1.08, p = 0.93, treatment 11 of 31 (35.5%), control 6 of 36 (16.7%), adjusted, OR converted to RR. Abdelwahab et al., 7/30/2021, retrospective, Egypt, Africa, peer-reviewed, 17 authors.
	Share Tweet Submit Corrections or Comments
Jun 8	Late	Horby et al., medRxiv, doi:10.1101/2021.06.08.21258132 (Preprint)	death, ↓4.0%, p=0.35	Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
	Details RCT 14,892 very late stage (9 days from symptom onset) hospitalized patients, not showing a significant difference in mortality with treatment. A statistically significant increased chance of hospital discharge was found for treatment <= ..
Jun 8	Details Source PDF Late treatment study Late treatment study
	Horby et al., medRxiv, doi:10.1101/2021.06.08.21258132 (Preprint)
	Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
	RCT 14,892 very late stage (9 days from symptom onset) hospitalized patients, not showing a significant difference in mortality with treatment. A statistically significant increased chance of hospital discharge was found for treatment <= 7 days from symptom onset (supplement page 52). Only 7% of patients were not receiving thromboprophylaxis. Authors note that the lack of benefit seen may be because there was no significant additional benefit given the high rates of antithrombotic therapy with LMWH. Authors also note that potential benefit may depend on treatment delay, especially if thrombi had developed before admission. Lower RR is shown for patients not on LMWH (0.83), and patients treated <= 7 days from onset (0.93). Results restricted to earlier treatment times are not provided. Patients already receiving aspirin were excluded. NCT04381936. risk of death, 4.0% lower, RR 0.96, p = 0.35, treatment 1222 of 7351 (16.6%), control 1299 of 7541 (17.2%). risk of death, 17.0% lower, RR 0.83, p = 0.11, treatment 129 of 466 (27.7%), control 169 of 513 (32.9%), no LMWH, supplement page 54. risk of death, 7.0% lower, RR 0.93, p = 0.25, treatment 1222 of 7351 (16.6%), control 1299 of 7541 (17.2%), <=7 days from onset, supplement page 52. risk of mechanical ventilation, 5.0% lower, RR 0.95, p = 0.32, treatment 772 of 6993 (11.0%), control 829 of 7169 (11.6%). Horby et al., 6/8/2021, Randomized Controlled Trial, United Kingdom, Europe, preprint, 35 authors.
	Share Tweet Submit Corrections or Comments
Apr 1	Late	Chow et al., Anesthesia & Analgesia, doi:10.1213/ANE.0000000000005292 (Peer Reviewed)	death, ↓47.0%, p=0.02	Aspirin Use Is Associated With Decreased Mechanical Ventilation, Intensive Care Unit Admission, and In-Hospital Mortality in Hospitalized Patients With Coronavirus Disease 2019
	Details Retrospective 412 hospitalized patients, 98 treated with aspirin, showing lower mortality, ventilation, and ICU admission with treatment.
Apr 1	Details Source PDF Late treatment study Late treatment study
	Chow et al., Anesthesia & Analgesia, doi:10.1213/ANE.0000000000005292 (Peer Reviewed)
	Aspirin Use Is Associated With Decreased Mechanical Ventilation, Intensive Care Unit Admission, and In-Hospital Mortality in Hospitalized Patients With Coronavirus Disease 2019
	Retrospective 412 hospitalized patients, 98 treated with aspirin, showing lower mortality, ventilation, and ICU admission with treatment. risk of death, 47.0% lower, RR 0.53, p = 0.02, treatment 26 of 98 (26.5%), control 73 of 314 (23.2%), adjusted, Cox proportional hazards. risk of mechanical ventilation, 44.0% lower, RR 0.56, p = 0.007, treatment 35 of 98 (35.7%), control 152 of 314 (48.4%), adjusted, Cox proportional hazards. risk of ICU admission, 43.0% lower, RR 0.57, p = 0.007, treatment 38 of 98 (38.8%), control 160 of 314 (51.0%), adjusted, Cox proportional hazards. Chow et al., 4/1/2021, retrospective, USA, North America, peer-reviewed, 38 authors.
	Share Tweet Submit Corrections or Comments
Feb 12	Late	Liu et al., Medicine, doi:10.1097/MD.0000000000024544 (Peer Reviewed)	death, ↓75.0%, p=0.03	Effect of low-dose aspirin on mortality and viral duration of the hospitalized adults with COVID-19
	Details Retrospective PSM analysis of 232 hospitalized patients, 28 treated with aspirin, showing lower mortality with treatment. There was no significant difference in viral clearance.
Feb 12	Details Source PDF Late treatment study Late treatment study
	Liu et al., Medicine, doi:10.1097/MD.0000000000024544 (Peer Reviewed)
	Effect of low-dose aspirin on mortality and viral duration of the hospitalized adults with COVID-19
	Retrospective PSM analysis of 232 hospitalized patients, 28 treated with aspirin, showing lower mortality with treatment. There was no significant difference in viral clearance. risk of death, 75.0% lower, RR 0.25, p = 0.03, treatment 2 of 28 (7.1%), control 11 of 204 (5.4%), adjusted, 60 days, KM, PSM. risk of death, 81.0% lower, RR 0.19, p = 0.02, treatment 1 of 28 (3.6%), control 9 of 204 (4.4%), adjusted, 30 days, KM, PSM. time to viral-, 1.9% higher, relative time 1.02, p = 0.94, treatment 24, control 24, PSM. Liu et al., 2/12/2021, retrospective, propensity score matching, China, Asia, peer-reviewed, 8 authors.
	Share Tweet Submit Corrections or Comments
Feb 11	PrEP	Osborne et al., PloS ONE, doi:10.1371/journal.pone.0246825 (Peer Reviewed)	death, ↓59.4%, p<0.0001	Association of mortality and aspirin prescription for COVID-19 patients at the Veterans Health Administration
	Details Retrospective PSM analysis of pre-existing aspirin use in the USA, showing lower mortality with treatment.
Feb 11	Details Source PDF Pre-Exposure Prophylaxis study Pre-Exposure Prophylaxis study
	Osborne et al., PloS ONE, doi:10.1371/journal.pone.0246825 (Peer Reviewed)
	Association of mortality and aspirin prescription for COVID-19 patients at the Veterans Health Administration
	Retrospective PSM analysis of pre-existing aspirin use in the USA, showing lower mortality with treatment. risk of death, 59.4% lower, RR 0.41, p < 0.001, treatment 272 of 6300 (4.3%), control 661 of 6300 (10.5%), OR converted to RR, 30 days, PSM. risk of death, 60.5% lower, RR 0.40, p < 0.001, treatment 170 of 6814 (2.5%), control 427 of 6814 (6.3%), OR converted to RR, 14 days, PSM. Osborne et al., 2/11/2021, retrospective, propensity score matching, USA, North America, peer-reviewed, 6 authors.
	Share Tweet Submit Corrections or Comments
Jan 21	Late	Meizlish et al., American Journal of Hematology, doi:10.1002/ajh.26102 (Peer Reviewed)	death, ↓47.8%, p=0.004	Intermediate-dose anticoagulation, aspirin, and in-hospital mortality in COVID-19: A propensity score-matched analysis
	Details Retrospective 638 matched hospitalized patients in the USA, 319 treated with aspirin, showing lower mortality with treatment.
Jan 21	Details Source PDF Late treatment study Late treatment study
	Meizlish et al., American Journal of Hematology, doi:10.1002/ajh.26102 (Peer Reviewed)
	Intermediate-dose anticoagulation, aspirin, and in-hospital mortality in COVID-19: A propensity score-matched analysis
	Retrospective 638 matched hospitalized patients in the USA, 319 treated with aspirin, showing lower mortality with treatment. risk of death, 47.8% lower, RR 0.52, p = 0.004, treatment 319, control 319, PSM. Meizlish et al., 1/21/2021, retrospective, propensity score matching, USA, North America, peer-reviewed, 22 authors.
	Share Tweet Submit Corrections or Comments
Dec 18 2020	PrEP	Yuan et al., Journal of Cellular and Molecular Medicine, doi:10.1111/jcmm.16198 (Peer Reviewed)	death, ↓4.4%, p=0.89	Mortality and pre-hospitalization use of low-dose aspirin in COVID-19 patients with coronary artery disease
	Details Retrospective 183 hospitalized patients in China, 52 taking low-dose aspirin prior to hospitalization, showing no significant difference with treatment.
Dec 18 2020	Details Source PDF Pre-Exposure Prophylaxis study Pre-Exposure Prophylaxis study
	Yuan et al., Journal of Cellular and Molecular Medicine, doi:10.1111/jcmm.16198 (Peer Reviewed)
	Mortality and pre-hospitalization use of low-dose aspirin in COVID-19 patients with coronary artery disease
	Retrospective 183 hospitalized patients in China, 52 taking low-dose aspirin prior to hospitalization, showing no significant difference with treatment. risk of death, 4.4% lower, RR 0.96, p = 0.89, treatment 11 of 52 (21.2%), control 29 of 131 (22.1%), OR converted to RR, mutivariate. Yuan et al., 12/18/2020, retrospective, China, Asia, peer-reviewed, 6 authors.
	Share Tweet Submit Corrections or Comments

Please send us corrections, updates, or comments. Vaccines and treatments are both extremely valuable and complementary. All practical, effective, and safe means should be used. Elimination of COVID-19 is a race against viral evolution. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. Denying the efficacy of any method increases the risk of COVID-19 becoming endemic; and increases mortality, morbidity, and collateral damage. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. Treatment protocols for physicians are available from the FLCCC.

Thanks for your feedback! Please search before submitting papers and note that studies are listed under the date they were first available, which may be the date of an earlier preprint.

Submit