Ghati, 661 patient aspirin late treatment RCT: 22% lower mortality [p=0.62], 9% lower ventilation [p=0.8], and 30% lower progression [p=0.46] https://c19p.org/ghati
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Statin and aspirin as adjuvant therapy in hospitalised patients with SARS-CoV-2 infection: a randomised clinical trial (RESIST trial)
et al., BMC Infectious Diseases, doi:10.1186/s12879-022-07570-5, CTRI/2020/07/026791
RCT hospitalized patients in India, 224 treated with atorvastatin, 225 with aspirin, and 225 with both, showing lower serum interleukin-6 levels with aspirin, but no statistically significant changes in other outcomes. Low dose aspirin 75mg daily for 10 days.
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risk of death, 22.1% lower, RR 0.78, p = 0.62, treatment 11 of 442 (2.5%), control 7 of 219 (3.2%), NNT 141, aspirin and aspirin/atorvastatin vs. control, modified intention-to-treat.
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risk of death, 57.5% lower, RR 0.42, p = 0.22, treatment 3 of 221 (1.4%), control 7 of 219 (3.2%), NNT 54, aspirin vs. control, modified intention-to-treat.
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risk of mechanical ventilation, 9.2% lower, RR 0.91, p = 0.80, treatment 11 of 442 (2.5%), control 6 of 219 (2.7%), NNT 398, aspirin and aspirin/atorvastatin vs. control, modified intention-to-treat.
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risk of mechanical ventilation, 50.5% lower, RR 0.50, p = 0.34, treatment 3 of 221 (1.4%), control 6 of 219 (2.7%), NNT 72, aspirin vs. control, modified intention-to-treat.
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risk of progression, 30.0% lower, HR 0.70, p = 0.46, treatment 11 of 442 (2.5%), control 7 of 219 (3.2%), NNT 141, aspirin and aspirin/atorvastatin vs. control, Cox proportional hazards, modified intention-to-treat, primary outcome.
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risk of progression, 60.0% lower, HR 0.40, p = 0.18, treatment 3 of 221 (1.4%), control 7 of 219 (3.2%), NNT 54, aspirin vs. control, Cox proportional hazards, modified intention-to-treat, primary outcome.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Ghati et al., 7/9/2022, Randomized Controlled Trial, India, peer-reviewed, 14 authors, study period 28 July, 2020 - 27 January, 2021, average treatment delay 6.0 days, trial CTRI/2020/07/026791 (RESIST).
Contact:
deeptikailath@gmail.com (corresponding author).
Late treatment
is less effective
is less effective
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