5/18 Prophylaxis study
et al., medRxiv, doi:10.1101/2020.05.04.20089904 (Preprint)
Association of previous medications with the risk of COVID-19: a nationwide claims-based study from South Korea
Association of previous medications with the risk of COVID-19: a nationwide claims-based study from South Korea
Retrospective database analysis of 65,149 in South Korea, showing significantly lower cases with existing aspirin treatment. The journal version of this paper does not present the aspirin results (only combined results for NSAIDs).
risk of case, 71.0% lower, RR 0.29, p = 0.001, treatment 8 of 543 (1.5%), control 5,164 of 64,606 (8.0%), adjusted per study.
Huh et al., 5/18/2020, retrospective, database analysis, South Korea, Asia, preprint, 10 authors.
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Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.
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