Retrospective 2,070 hospitalized patients in the USA, showing lower mortality with aspirin treatment.
Zhao et al., 10/1/2021, retrospective, USA, North America, peer-reviewed, 6 authors.
risk of death, 43.0% lower, RR 0.57, p < 0.001, treatment 121 of 473 (25.6%), control 140 of 473 (29.6%), adjusted per study, PSM.
risk of death, 28.0% lower, RR 0.72, p = 0.03, treatment 473, control 1597, adjusted per study, multivariable.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.