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Aspirin study #22   All Outcomes
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 71% Imp. Relative Risk, 95% CI Santoro: Antiplatelet therapy and outcome in patients with COVID-.. c19aspirin.com/santoro.html Favors aspirin Favors control
10/14 Late treatment study
Santoro et al., European Heart Journal, doi:10.1093/eurheartj/ehab724.3002 (Peer Reviewed)
Antiplatelet therapy and outcome in patients with COVID-19. Results from a multi-center international prospective registry (HOPE-COVID19)
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Retrospective database analysis of 7,824 patients in the HOPE-COVID19 registry, 730 receiving antiplatelet therapy including aspirin, showing lower mortality with treatment. Authors do not provide results restricted to aspirin.
risk of death, 71.0% lower, RR 0.29, p < 0.001, treatment 730, control 7,094, antiplatelet therapy, multivariable.
Santoro et al., 10/14/2021, retrospective, multiple countries, multiple regions, peer-reviewed, 6 authors.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
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