RECOVERY, 14,892 patient aspirin late treatment RCT: 4% lower mortality [p=0.35], 5% lower ventilation [p=0.32], 6% higher hospital discharge [p=0.006], and 11% shorter hospitalization https://c19p.org/recoverye
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Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
Collaborative Group, The Lancet, doi:10.1016/S0140-6736(21)01825-0
RCT 14,892 late stage patients, 7,351 treated with aspirin, showing slightly improved discharge and hospitalization time, and no significant difference for mortality.Results are limited due to low dose (150mg daily), very late treatment (9 days post symptom onset), and 96% concurrent use of low molecular weight heparin. Greater benefits were seen for non-LMWH patients, and for very late (<= 7 days from onset) vs. extremely late (>7 days) treatment. For more discussion see [twitter.com].
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risk of death, 4.0% lower, RR 0.96, p = 0.35, treatment 7,351, control 7,541.
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risk of death, 17.0% lower, RR 0.83, p = 0.35, treatment 7,351, control 7,541, non-LMWH.
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risk of mechanical ventilation, 5.0% lower, RR 0.95, p = 0.32, treatment 7,351, control 7,541.
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risk of no hospital discharge, 5.7% lower, RR 0.94, p = 0.006, treatment 7,351, control 7,541.
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risk of no hospital discharge, 16.0% lower, RR 0.84, p = 0.04, treatment 7,351, control 7,541, non-LMWH.
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hospitalization time, 11.1% lower, relative time 0.89, treatment 7,351, control 7,541.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
RECOVERY et al., 11/18/2021, Randomized Controlled Trial, multiple countries, multiple regions, peer-reviewed, 1 author, study period 1 November, 2020 - 21 March, 2021, average treatment delay 9.0 days.
Late treatment
is less effective
is less effective
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