RECOVERY: Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

RECOVERY, 14,892 patient aspirin late treatment RCT: 4% lower mortality [p=0.35], 5% lower ventilation [p=0.32], 6% higher hospital discharge [p=0.006], and 11% shorter hospitalization https://c19p.org/recoverye

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Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

RECOVERY Collaborative Group, The Lancet, doi:10.1016/S0140-6736(21)01825-0, RECOVERY

18 Nov 2021 Source PDF Share Tweet

RCT 14,892 late stage patients, 7,351 treated with aspirin, showing slightly improved discharge and hospitalization time, and no significant difference for mortality.

Results are limited due to low dose (150mg daily), very late treatment (9 days post symptom onset), and 96% concurrent use of low molecular weight heparin. Greater benefits were seen for non-LMWH patients, and for very late (<= 7 days from onset) vs. extremely late (>7 days) treatment. For more discussion see [twitter.com].

1. twitter.com, https://twitter.com/Covid19Crusher/status/1461272964675031042.

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risk of death, 4.0% lower, RR 0.96, p = 0.35, treatment 7,351, control 7,541.

risk of death, 17.0% lower, RR 0.83, p = 0.35, treatment 7,351, control 7,541, non-LMWH.

risk of mechanical ventilation, 5.0% lower, RR 0.95, p = 0.32, treatment 7,351, control 7,541.

risk of no hospital discharge, 5.7% lower, RR 0.94, p = 0.006, treatment 7,351, control 7,541, inverted to make RR<1 favor treatment.

risk of no hospital discharge, 16.0% lower, RR 0.84, p = 0.04, treatment 7,351, control 7,541, inverted to make RR<1 favor treatment, non-LMWH.

hospitalization time, 11.1% lower, relative time 0.89, treatment 7,351, control 7,541.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

RECOVERY et al., 18 Nov 2021, Randomized Controlled Trial, multiple countries, peer-reviewed, 1 author, study period 1 November, 2020 - 21 March, 2021, average treatment delay 9.0 days, RECOVERY trial.

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This Paper Aspirin All

Late treatment
is less effective

Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.

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