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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 59% Improvement Relative Risk Mortality (b) 60% c19aspirin.com/osborne.html Favors aspirin Favors control
11 February 2021 - Prophylaxis study
Association of mortality and aspirin prescription for COVID-19 patients at the Veterans Health Administration
Osborne et al., PloS ONE, doi:10.1371/journal.pone.0246825 (Peer Reviewed)
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Retrospective PSM analysis of pre-existing aspirin use in the USA, showing lower mortality with treatment.
risk of death, 59.4% lower, RR 0.41, p < 0.001, treatment 272 of 6,300 (4.3%), control 661 of 6,300 (10.5%), NNT 16, odds ratio converted to relative risk, 30 days, PSM.
risk of death, 60.5% lower, RR 0.40, p < 0.001, treatment 170 of 6,814 (2.5%), control 427 of 6,814 (6.3%), NNT 27, odds ratio converted to relative risk, 14 days, PSM.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Osborne et al., 2/11/2021, retrospective, propensity score matching, USA, North America, peer-reviewed, 6 authors.
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