Retrospective PSM analysis of pre-existing aspirin use in the USA, showing lower mortality with treatment.
Osborne et al., 2/11/2021, retrospective, propensity score matching, USA, North America, peer-reviewed, 6 authors.
risk of death, 59.4% lower, RR 0.41, p < 0.001, treatment 272 of 6300 (4.3%), control 661 of 6300 (10.5%), odds ratio converted to relative risk, 30 days, PSM.
risk of death, 60.5% lower, RR 0.40, p < 0.001, treatment 170 of 6814 (2.5%), control 427 of 6814 (6.3%), odds ratio converted to relative risk, 14 days, PSM.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.