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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 15% Improvement Relative Risk Mortality (b) 37% c19aspirin.com/mura.html Favors aspirin Favors control
31 March 2021 - Late treatment study
Real-world evidence for improved outcomes with histamine antagonists and aspirin in 22,560 COVID-19 patients
Mura et al., Signal Transduction and Targeted Therapy, doi:10.1038/s41392-021-00689-y (preprint 3/31/2021) (Peer Reviewed)
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PSM retrospective TriNetX database analysis of 1,379 severe COVID-19 patients requiring respiratory support, showing lower mortality with aspirin (not reaching statistical significance) and famotidine, and improved results from the combination of both.
risk of death, 15.4% lower, RR 0.85, p = 0.08, treatment 527, control 527, odds ratio converted to relative risk, aspirin only, control prevalence approximated with treatment prevalence, propensity score matching.
risk of death, 37.3% lower, RR 0.63, p = 0.001, treatment 305, control 305, odds ratio converted to relative risk, famotidine and aspirin, control prevalence approximated with treatment prevalence, propensity score matching.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Mura et al., 3/31/2021, retrospective, database analysis, multiple countries, multiple regions, peer-reviewed, 6 authors.
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