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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Death/hospitalization 59% primary Improvement Relative Risk Death/hospitalization (b) 71% Mortality 15% unadjusted Ventilation 9% unadjusted Hospitalization 48% unadjusted Progression 42% unadjusted c19aspirin.com de Jesús Ascencio-Montiel et al. Aspirin EARLY Favors aspirin Favors control
de Jesús Ascencio-Montiel, 28,048 patient aspirin early treatment study: 59% lower combined mortality/hospitalization [p<0.0001], 15% lower mortality [p=0.16], 9% lower ventilation [p=0.51], and 48% lower hospitalization [p<0.0001] https://c19p.org/dejesusascenciomontiele
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A Multimodal Strategy to Reduce the Risk of Hospitalization/death in Ambulatory Patients with COVID-19
de Jesús Ascencio-Montiel et al., Archives of Medical Research, doi:10.1016/j.arcmed.2022.01.002
24 Jan 2022    Source   PDF   Share   Tweet
Retrospective 28,048 COVID+ patients in Mexico, 7,898 receiving a treatment kit including low dose ivermectin, AZ, aspirin, and acetaminophen, shower lower mortality/hospitalization for those receiving the kit. Delivery of the treatment kit was based on availability in the medical units. Adherence is unknown and may be low. Adjusted results are only provided for combined mortality/hospitalization.
risk of death/hospitalization, 59.0% lower, RR 0.41, p < 0.001, treatment 7,898, control 20,150, adjusted per study, multivariable, primary outcome.
risk of death/hospitalization, 71.0% lower, RR 0.29, p < 0.001, treatment 5,557, control 12,526, adjusted per study, with phone call followup, multivariable.
risk of death, 15.0% lower, RR 0.85, p = 0.16, treatment 101 of 7,898 (1.3%), control 303 of 20,150 (1.5%), NNT 445, unadjusted, excluded in exclusion analyses: unadjusted results with alternate outcome adjusted results showing significant changes with adjustments.
risk of mechanical ventilation, 9.1% lower, RR 0.91, p = 0.51, treatment 77 of 7,898 (1.0%), control 216 of 20,150 (1.1%), NNT 1031, unadjusted, excluded in exclusion analyses: unadjusted results with alternate outcome adjusted results showing significant changes with adjustments.
risk of hospitalization, 47.6% lower, RR 0.52, p < 0.001, treatment 485 of 7,898 (6.1%), control 2,360 of 20,150 (11.7%), NNT 18, unadjusted, excluded in exclusion analyses: unadjusted results with alternate outcome adjusted results showing significant changes with adjustments.
risk of progression, 41.8% lower, RR 0.58, p < 0.001, treatment 435 of 7,898 (5.5%), control 1,906 of 20,150 (9.5%), NNT 25, unadjusted, ER, excluded in exclusion analyses: unadjusted results with alternate outcome adjusted results showing significant changes with adjustments.
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This study is excluded in meta analysis: combined treatments may contribute more to the effect seen.
de Jesús Ascencio-Montiel et al., 1/24/2022, retrospective, Mexico, North America, peer-reviewed, 10 authors, this trial uses multiple treatments in the treatment arm (combined with AZ, acetaminophen, ivermectin) - results of individual treatments may vary.
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