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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 19% Improvement Relative Risk Mechanical ventilation 3% c19aspirin.com/chow2.html Favors aspirin Favors control
29 August 2021 - Prophylaxis study
Association of Pre-Hospital Antiplatelet Therapy with Survival in Patients Hospitalized with COVID-19: A Propensity Score-Matched Analysis
Chow et al., Journal of Thrombosis and Haemostasis, doi:10.1111/jth.15517 (Peer Reviewed)
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PSM retrospective 6,781 hospitalized patients ≥50 years old in the USA who were on pre-hospital antiplatelet therapy (84% aspirin), and 10,566 matched controls, showing lower mortality with treatment.
risk of death, 19.0% lower, RR 0.81, p < 0.005, treatment 1,280 of 6,781 (18.9%), control 2,271 of 10,566 (21.5%), NNT 38, adjusted per study, Kaplan Meier.
risk of mechanical ventilation, 2.8% lower, RR 0.97, p = 0.21, treatment 2,122 of 6,781 (31.3%), control 3,403 of 10,566 (32.2%), NNT 109.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Chow et al., 8/29/2021, retrospective, propensity score matching, USA, North America, peer-reviewed, 12 authors.
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