PSM retrospective 6,781 hospitalized patients ≥50 years old in the USA who were on pre-hospital antiplatelet therapy (84% aspirin), and 10,566 matched controls, showing lower mortality with treatment.
Chow et al., 8/29/2021, retrospective, propensity score matching, USA, North America, peer-reviewed, 12 authors.
risk of death, 19.0% lower, RR 0.81, p < 0.005, treatment 1280 of 6781 (18.9%), control 2271 of 10566 (21.5%), adjusted per study, Kaplan Meier.
risk of mechanical ventilation, 2.8% lower, RR 0.97, p = 0.21, treatment 2122 of 6781 (31.3%), control 3403 of 10566 (32.2%).
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.