et al., Tohoku J. Exp. Med., 2020, 252, 73-84,
Retrospective 459 patients in Iran, 53 treated with aspirin, showing no significant difference with treatment.
risk of death, 27.7% higher, RR 1.28, p = 0.52, treatment 9 of 53 (17.0%), control 54 of 406 (13.3%).
This study is excluded in the after exclusion results of meta
substantial unadjusted confounding by indication likely.
Alamdari et al., 9/9/2020, retrospective, Iran, Middle East, peer-reviewed, 14 authors.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.