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0 0.5 1 1.5 2+ Mortality, day 56 33% Improvement Relative Risk Mortality, day 30 40% Hospitalization 20% c19aspirin.com Abul et al. Aspirin for COVID-19 Prophylaxis Favors aspirin Favors control
Abul, 1,687 patient aspirin prophylaxis study: 33% lower mortality [p=0.03] and 20% lower hospitalization [p=0.13] https://c19p.org/abul
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Association of mortality and aspirin use for COVID-19 residents at VA Community Living Center Nursing Homes
Abul et al., medRxiv, doi:10.1101/2022.08.03.22278392 (Preprint)
4 Aug 2022    Source   PDF   Share   Tweet
Retrospective 1,687 nursing home residents in the USA, showing significantly lower risk of mortality with chronic low-dose aspirin use. Low dose 81mg aspirin users had treatment ≥10 of 14 days prior to the positive COVID date, control patients had no aspirin use in the prior 14 days.
risk of death, 33.0% lower, HR 0.67, p = 0.03, treatment 46 of 511 (9.0%), control 201 of 1,176 (17.1%), Cox proportional hazards, day 56.
risk of death, 40.0% lower, HR 0.60, p = 0.01, treatment 33 of 511 (6.5%), control 154 of 1,176 (13.1%), Cox proportional hazards, day 30.
risk of hospitalization, 20.0% lower, HR 0.80, p = 0.13, treatment 103 of 511 (20.2%), control 352 of 1,176 (29.9%), Cox proportional hazards.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Abul et al., 8/4/2022, retrospective, USA, preprint, mean age 72.3, 10 authors, study period 13 December, 2020 - 18 September, 2021.
Contact: yasin_abul@brown.edu.
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